Shaik Imthiyaz Ahmed

List of Nobel Prize Winners in Physiology / Medicine 2014 – Current Affairs

The Nobel Prize in Physiology or Medicine is awarded annually by the Swedish Karolinska Institute to scientists and doctors in the various fields of physiology or medicine. It is one of the five Nobel Prizes established by the 1895 will of Alfred Nobel (who died in 1896), awarded for outstanding contributions in chemistry, physics, literature, peace, and physiology or medicine. As dictated by Nobel’s will, the award is administered by the Nobel Foundation and awarded by a committee that consists of five members and an executive secretary elected by the Karolinska Institute. While commonly referred to as the Nobel Prize in Medicine, Nobel specifically stated that the prize be awarded for “physiology or medicine” in his will. Because of this, the prize can be awarded in a broader range of fields. The first Nobel Prize in Physiology or Medicine was awarded in 1901 to Emil Adolf von Behring, of Germany. Each recipient receives a medal, a diploma and a monetary award that has varied throughout the years. In 1901, von Behring received 150,782 SEK, which is equal to 7,731,004 SEK in December 2008. In 2013, the prize was awarded to James E. Rothman, Randy W. Schekman and Thomas C.they were recognised “after discovering how cells precisely transport material”. The award is presented in Stockholm at an annual ceremony on December 10, the anniversary of Nobel’s death.

The Nobel Prize in Physiology or Medicine has been awarded 105 times to 207 Nobel Laureates between 1901 and 2014. Laureates have won the Nobel Prize in a wide range of fields that relate to physiology or medicine. As of 2009, 8 Prizes have been awarded for contributions in the field of signal transduction by G proteins and second messengers, 13 have been awarded for contributions in the field of neurobiology and 13 have been awarded for contributions in Intermediary Metabolism. Gerhard Domagk (1939), a German, was not allowed by his government to accept the prize. He later received a medal and diploma, but not the money. Eleven women have won the prize: Gerty Cori (1947), Rosalyn Yalow (1977), Barbara McClintock (1983), Rita Levi-Montalcini (1986), Gertrude B. Elion (1988), Christiane Nüsslein-Volhard (1995), Linda B. Buck (2004), Françoise Barré-Sinoussi (2008), Elizabeth H. Blackburn (2009), Carol W. Greider (2009), and May-Britt Moser As of 2013, the prize has been awarded to 204 individuals. There have been nine years in which the Nobel Prize in Physiology or Medicine was not awarded (1915–1918, 1921, 1925, 1940–1942).

Nobel Prize for Physiology or Medicine:

1901: Emil A. von Behring (Germany), for work on serum therapy against diphtheria

1902: Sir Ronald Ross (U.K.), for work on malaria

1903: Niels R. Finsen (Denmark), for his treatment of lupus vulgaris with concentrated light rays

1904: Ivan P. Pavlov (U.S.S.R.), for work on the physiology of digestion

1905: Robert Koch (Germany), for work on tuberculosis

1906: Camillo Golgi (Italy) and Santiago Ramón y Cajal (Spain), for work on structure of the nervous system

1907: Charles L. A. Laveran (France), for work with protozoa in the generation of disease

1908: Paul Ehrlich (Germany) and Elie Metchnikoff (Russia), for work on immunity

1909: Theodor Kocher (Switzerland), for work on the thyroid gland

1910: Albrecht Kossel (Germany), for achievements in the chemistry of the cell

1911: Allvar Gullstrand (Sweden), for work on the dioptrics of the eye

1912: Alexis Carrel (France), for work on vascular ligature and grafting of blood vessels and organs

1913: Charles Richet (France), for work on anaphylaxy

1914: Robert Bárány (Austria), for work on physiology and pathology of the vestibular system

1919: Jules Bordet (Belgium), for discoveries in connection with immunity

1920: August Krogh (Denmark), for discovery of regulation of capillaries’ motor mechanism

1922: In 1923, the 1922 prize was shared by Archibald V. Hill (U.K.), for discovery relating to heat-production in muscles; and Otto Meyerhof (Germany), for correlation between consumption of oxygen and production of lactic acid in muscles

1923: Sir Frederick Banting (Canada) and John J. R. Macleod (Scotland), for discovery of insulin

1924: Willem Einthoven (Netherlands), for discovery of the mechanism of the electrocardiogram

1926: Johannes Fibiger (Denmark), for discovery of the Spiroptera carcinoma

1927: Julius Wagner-Jauregg (Austria), for use of malaria inoculation in treatment of dementia paralytica

1928: Charles Nicolle (France), for work on typhus exanthematicus

1929: Christiaan Eijkman (Netherlands), for discovery of the antineuritic vitamins; and Sir Frederick Hopkins (U.K.), for discovery of growth-promoting vitamins

1930: Karl Landsteiner (U.S.), for discovery of human blood groups

1931: Otto H. Warburg (Germany), for discovery of the character and mode of action of the respiratory ferment

1932: Sir Charles Sherrington (U.K.) and Edgar D. Adrian (U.S.), for discoveries of the function of the neuron

1933: Thomas H. Morgan (U.S.), for discoveries on hereditary function of the chromosomes

1934: George H. Whipple, George R. Minot, and William P. Murphy (U.S.), for discovery of liver therapy against anemias

1935: Hans Spemann (Germany), for discovery of the organizer effect in embryonic development

1936: Sir Henry Dale (U.K.) and Otto Loewi (Germany), for discoveries on chemical transmission of nerve impulses

1937: Albert Szent-Györgyi von Nagyrapolt (Hungary), for discoveries on biological combustion

1938: Corneille Heymans (Belgium), for determining importance of sinus and aorta mechanisms in the regulation of respiration

1939: Gerhard Domagk (Germany), for antibacterial effect of prontocilate

1943: Henrik Dam (Denmark) and Edward A. Doisy (U.S.), for analysis of vitamin K

1944: Joseph Erlanger and Herbert Spencer Gasser (both U.S.), for work on functions of the nerve threads

1945: Sir Alexander Fleming, Ernst Boris Chain, and Sir Howard Florey (all U.K.), for discovery of penicillin

1946: Herman J. Muller (U.S.), for hereditary effects of X-rays on genes

1947: Carl F. and Gerty T. Cori (U.S.), for work on animal starch metabolism; Bernardo A. Houssay (Argentina), for study of pituitary

1948: Paul Mueller (Switzerland), for discovery of insect-killing properties of DDT

1949: Walter Rudolf Hess (Switzerland), for research on brain control of body; and Antonio Caetano de Abreu Freire Egas Moniz (Portugal), for development of brain operation

1950: Philip S. Hench, Edward C. Kendall (both U.S.), and Tadeus Reichstein (Switzerland), for discoveries about hormones of adrenal cortex

1951: Max Theiler (South Africa), for development of anti-yellow-fever vaccine

1952: Selman A. Waksman (U.S.), for co-discovery of streptomycin

1953: Fritz A. Lipmann (Germany-U.S.) and Hans Adolph Krebs (Germany-U.K.), for studies of living cells

1954: John F. Enders, Thomas H. Weller, and Frederick C. Robbins (all U.S.), for work with cultivation of polio virus

1955: Hugo Theorell (Sweden), for work on oxidation enzymes

1956: Dickinson W. Richards, Jr., André F. Cournand (both U.S.), and Werner Forssmann (Germany), for new techniques in treating heart disease

1957: Daniel Bovet (Italy), for development of drugs to relieve allergies and relax muscles during surgery

1958: Joshua Lederberg (U.S.), for work with genetic mechanisms; George W. Beadle and Edward L. Tatum (both U.S.), for discovering how genes transmit hereditary characteristics

1959: Severo Ochoa and Arthur Kornberg (both U.S.), for discoveries related to compounds within chromosomes that play a vital role in heredity

1960: Sir Macfarlane Burnet (Australia) and Peter Brian Medawar (U.K.), for discovery of acquired immunological tolerance

1961: Georg von Bekesy (U.S.), for discoveries about physical mechanisms of stimulation within cochlea

1962: James D. Watson (U.S.), Maurice H. F. Wilkins, and Francis H. C. Crick (both U.K.), for determining structure of deoxyribonucleic acid (DNA)

1963: Alan Lloyd Hodgkin, Andrew Fielding Huxley (both U.K.), and Sir John Carew Eccles (Australia), for research on nerve cells

1964: Konrad E. Bloch (U.S.) and Feodor Lynen (Germany), for research on mechanism and regulation of cholesterol and fatty-acid metabolism

1965: François Jacob, André Lwoff, and Jacques Monod (all France), for study of regulatory activities in body cells

1966: Charles Brenton Huggins (U.S.), for studies in hormone treatment of cancer of prostate; Francis Peyton Rous (U.S.), for discovery of tumor-producing viruses

1967: Haldan K. Hartline, George Wald (both U.S.), and Ragnar Granit (Sweden), for work on human eye

1968: Robert W. Holley, Har Gobind Khorana, and Marshall W. Nirenberg (all U.S.), for studies of genetic code

1969: Max Delbruck, Alfred D. Hershey, and Salvador E. Luria (all U.S.), for study of mechanism of virus infection in living cells

1970: Julius Axelrod (U.S.), Ulf S. von Euler (Sweden), and Sir Bernard Katz (U.K.), for studies of how nerve impulses are transmitted within the body

1971: Earl W. Sutherland, Jr. (U.S.), for research on how hormones work

1972: Gerald M. Edelman (U.S.), and Rodney R. Porter (U.K.), for research on the chemical structure and nature of antibodies

1973: Karl von Frisch, Konrad Lorenz (both Austria), and Nikolaas Tinbergen (Netherlands), for their studies of individual and social behavior patterns

1974: George E. Palade, Christian de Duve (both U.S.), and Albert Claude (Belgium), for contributions to understanding inner workings of living cells

1975: David Baltimore, Howard M. Temin, and Renato Dulbecco (all U.S.), for work in interaction between tumor viruses and genetic material of the cell

1976: Baruch S. Blumberg and D. Carleton Gajdusek (both U.S.), for discoveries concerning new mechanisms for the origin and dissemination of infectious diseases

1977: Rosalyn S. Yalow, Roger C. L. Guillemin, and Andrew V. Schally (all U.S.), for research in role of hormones in chemistry of the body

1978: Daniel Nathans, Hamilton Smith (both U.S.), and Werner Arber (Switzerland), for discovery of restriction enzymes and their application to problems of molecular genetics

1979: Allan MacLeod Cormack (U.S.) and Godfrey Newbold Hounsfield (U.K.), for developing computed axial tomography (CAT scan) X-ray technique

1980: Baruj Benacerraf, George D. Snell (both U.S.), and Jean Dausset (France), for discoveries that explain how the structure of cells relates to organ transplants and diseases

1981: Roger W. Sperry, David H. Hubel (both U.S.), and Torsten N. Wiesel (Sweden), for studies vital to understanding the organization and functioning of the brain

1982: Sune Bergstrom, Bengt Samuelsson (both Sweden), and John R. Vane (U.K.), for research in prostaglandins, hormonelike substances involved in a wide range of illnesses

1983: Barbara McClintock (U.S.), for her discovery of mobile genes in the chromosomes of a plant that change the future generations of plants they produce

1984: Cesar Milstein (U.K./Argentina), Georges J. F. Kohler (West Germany), and Niels K. Jerne (U.K./Denmark), for their work in immunology

1985: Michael S. Brown and Joseph L. Goldstein (both U.S.), for their work, which has drastically widened our understanding of the cholesterol metabolism and increased our possibilities to prevent and treat atherosclerosis and heart attacks

1986: Rita Levi-Montalcini (dual U.S./Italy) and Stanley Cohen (U.S.), for their contributions to the understanding of substances that influence cell growth

1987: Susumu Tonegawa (Japan), for his discoveries of how the body can suddenly marshal its immunological defenses against millions of different disease agents that it has never encountered before

1988: Gertrude B. Elion, George H. Hitchings (both U.S.), and Sir James Black (U.K.), for their discoveries of important principles for drug treatment

1989: J. Michael Bishop and Harold E. Varmus (both U.S.), for their unifying theory of cancer development

1990: Joseph E. Murray and E. Donnall Thomas (both U.S.), for their pioneering work in transplants

1991: Erwin Neher and Bert Sakmann (both Germany), for their research, particularly for the development of a technique called patch clamp

1992: Edmond H. Fischer and Edwin G. Krebs (both U.S.), for their discovery of a regulatory mechanism affecting almost all cells

1993: Phillip A. Sharp (U.S.) and Richard J. Roberts (U.K.), for their independent discovery in 1977 of “split genes”

1994: Alfred G. Gilman and Martin Rodbell (both U.S.), for discovery of G-proteins that help cells respond to outside signals

1995: Edward B. Lewis, Eric F. Wieschaus (both U.S.), and Christiane Nüsslein-Volhard (Germany), for studies of the fruit fly that will help explain congenital malformations in humans

1996: Peter C. Doherty (Australia) and Rolf M. Zinkernagel (Switzerland), for discoveries about how the immune system recognizes virus-infected cells

1997: Stanley B. Prusiner (U.S.), for discovery of a new type of germ, called prions, that causes degenerative brain disorders

1998: Robert F. Furchgott, Louis J. Ignarro, and Ferid Murad (all U.S.), for discovering that nitric oxide acts as a signal in the cardiovascular system

1999: Günter Blobel (Germany and U.S.), for discovering that proteins have signals that govern their transport and localization in the cell

2000: Arvid Carlsson (Sweden), Paul Greengard, and Eric Kandel (both U.S.), for discoveries concerning signal transduction in the nervous system

2001: Leland H. Hartwell (U.S.), R. Timothy Hunt, and Paul M. Nurse (both UK), for discoveries concerning control of the cell cycle, which may make new cancer treatments possible.

2002: Sydney Brenner (UK), H. Robert Horvitz (U.S.), and John E. Sulston (UK) for discoveries concerning genetic regulation of organ development and programmed cell death.

2003: Paul C. Lauterbur (U.S.) and Sir Peter Mansfield (UK) for discoveries leading to magnetic resonance imaging (MRI).

2004: Richard Axel and Linda Buck (both U.S.) “for their discoveries of odorant receptors and the organization of the olfactory system.”

2005: Barry J. Marshall and J. Robin Warren (both Australia)

2006: Andrew Z. Fire and Craig C. Mello (both U.S.) for “their discovery of RNA interference – gene silencing by double-stranded RNA”

2007: Mario R. Capecchi (U.S.), Sir Martin J. Evans (U.K.), and Oliver Smithies (U.S.) for “their discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem cells”

2008: Harald zur Hausen (Germany) for his discovery that the human papilloma viruses (HPV) causes cervical cancer and to Françoise Barré-Sinoussi and Luc Montagnier (both France) for their discovery of the human immunodeficiency virus (HIV)

2009: Elizabeth H. Blackburn, Carol W. Greider, and Jack W. Szostak (all U.S) for “the discovery of how chromosomes are protected by telomeres and the enzyme telomerase”

2010: Robert G. Edwards (UK) for “for the development of in vitro fertilization”

2011: One-half jointly to Bruce A. Beutler (U.S.) and Jules A. Hoffmann (Luxembourg) “for their discoveries concerning the activation of innate immunity”; and one-half to Ralph M. Steinman (Canada) “for his discovery of the dendritic cell and its role in adaptive immunity”

2012: Jointly to Sir John B. Gurdon (UK) and Shinya Yamanaka (Japan) “for the discovery that mature cells can be reprogrammed to become pluripotent”

2013: Jointly to James E. Rothman (U.S.), Randy W. Schekman (U.S.), and Thomas C. Südhof (Germany) for “their discoveries of machinery regulating vesicle traffic, a major transport system in our cells”

2014: One-half jointly to May-Britt Moser (Norway) and Edvard I. Moser (Norway), and one-half to John O’Keefe (U.S. and UK), for “their discoveries of cells that constitute a positioning system in the brain”

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